Talk Python to Me is a weekly podcast hosted by developer and entrepreneur Michael Kennedy. We dive deep into the popular packages and software developers, data scientists, and incredible hobbyists doing amazing things with Python. If you're new to Python, you'll quickly learn the ins and outs of the community by hearing from the leaders. And if you've been Pythoning for years, you'll learn about your favorite packages and the hot new ones coming out of open source.
#520: pyx - the other side of the uv coin (announcing pyx)
September 23, 2025
01:00:11
58.06 MB
Downloads: 0
A couple years ago, Charlie Marsh lit a fire under Python tooling with Ruff and then uv. Today he’s back with something on the other side of that coin: pyx.
Pyx isn’t a PyPI replacement. Think server, not just index. It mirrors PyPI, plays fine with pip or uv, and aims to make installs fast and predictable by letting a smart client talk to a smart server. When the client and server understand each other, you get new fast paths, fewer edge cases, and the kind of reliability teams beg for. If Python packaging has felt like friction, this conversation is traction. Let’s get into it.
Episode sponsors
Six Feet Up
Talk Python Courses
Charlie Marsh on Mastodon: @charliermarsh
Astral Homepage: astral.sh
Pyx Project: astral.sh
Introducing Pyx Blog Post: astral.sh
uv Package on GitHub: github.com
UV Star History Chart: star-history.com
Watch this episode on YouTube: youtube.com
Episode #520 deep-dive: talkpython.fm/520
Episode transcripts: talkpython.fm
Developer Rap Theme Song: Served in a Flask: talkpython.fm/flasksong
--- Stay in touch with us ---
Subscribe to Talk Python on YouTube: youtube.com
Talk Python on Bluesky: @talkpython.fm at bsky.app
Talk Python on Mastodon: talkpython
Michael on Bluesky: @mkennedy.codes at bsky.app
Michael on Mastodon: mkennedy
Pyx isn’t a PyPI replacement. Think server, not just index. It mirrors PyPI, plays fine with pip or uv, and aims to make installs fast and predictable by letting a smart client talk to a smart server. When the client and server understand each other, you get new fast paths, fewer edge cases, and the kind of reliability teams beg for. If Python packaging has felt like friction, this conversation is traction. Let’s get into it.
Episode sponsors
Six Feet Up
Talk Python Courses
Links from the show
Charlie Marsh on Twitter: @charliermarshCharlie Marsh on Mastodon: @charliermarsh
Astral Homepage: astral.sh
Pyx Project: astral.sh
Introducing Pyx Blog Post: astral.sh
uv Package on GitHub: github.com
UV Star History Chart: star-history.com
Watch this episode on YouTube: youtube.com
Episode #520 deep-dive: talkpython.fm/520
Episode transcripts: talkpython.fm
Developer Rap Theme Song: Served in a Flask: talkpython.fm/flasksong
--- Stay in touch with us ---
Subscribe to Talk Python on YouTube: youtube.com
Talk Python on Bluesky: @talkpython.fm at bsky.app
Talk Python on Mastodon: talkpython
Michael on Bluesky: @mkennedy.codes at bsky.app
Michael on Mastodon: mkennedy