The Huberman Lab Podcast discusses neuroscience: how our brain and its connections with the organs of our body control our perceptions, our behaviors, and our health. We also discuss existing and emerging tools for measuring and changing how our nervous system works. Dr. Andrew Huberman is a tenured Professor of Neurobiology and Ophthalmology at Stanford School of Medicine. His laboratory studies neural regeneration, neuroplasticity, and brain states such as stress, focus, fear, and optimal performance. For more than 20 years, Dr. Huberman has consistently published original research findings and review articles in top-level peer-reviewed journals, including Nature, Science, Cell, Neuron, and Current Biology. He is a regular member of several National Institutes of Health review panels and a Fellow of the McKnight Foundation and the Pew Charitable Trusts. Dr. Huberman regularly consults for technology development companies, professional athletic organizations, and various units of U.S. and Canadian Special Operations.

Improve Energy & Longevity by Optimizing Mitochondria | Dr. Martin Picard

December 15, 2025 3:16:45 33.76 MB ( -33.77 MB less) Downloads: 0

Dr. Martin Picard, PhD, is a professor of behavioral medicine at Columbia University and an expert on how our behaviors and psychology shape cellular energy production and rates of aging. He explains that your mitochondria don’t just “make energy”; they translate what you do—your mindset and your relationships—into the energy you experience as vitality or lack thereof. He explains how exercise, nutrition, sleep, meditation, and even certain thought patterns and our sense of purpose can charge our cells like batteries. He also shares findings that hair greying is the result of cellular stress and is reversible. This episode links physical and mental ‘energy’ with cellular energy and provides science-supported tools to improve your physical and mental health.

Read the episode show notes at hubermanlab.com.

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Timestamps

(00:00:00) Martin Picard

(00:03:50) What is Energy?, Energy Flow & Transformation

(00:07:53) Energy, Vitality, Emotions, Sensory Perception

(00:14:18) Sponsors: Helix Sleep & Lingo

(00:17:19) “Mito-Centric” View of World, Mitochondrial Energy & Information Patterns

(00:25:26) Organelles, Mitochondria & Energy Transformation; Maternal Genes

(00:31:12) Mitotypes & Differentiation, Mitochondria as “Social Organisms”

(00:36:52) Food & Dysfunctional Energy Transformation

(00:40:02) Lifestyle Choices & Interests, Physiological Growth

(00:46:39) Pregnancy, Amenorrhea; Illness & Tiredness

(00:51:07) Sponsor: AG1

(00:52:29) Energy Transformation & Distribution; Body’s Wisdom, Feeling Sick

(00:56:27) Tool: Feel Your Energy; Breath & Energy

(01:02:31) Flow of Energy; Trade-Offs, Life Purpose & Enjoyment

(01:10:15) Biology, Meaningful Experiences & Energy Flow

(01:16:27) Sponsor: Function

(00:18:15) Inflammation, Energetic Flow

(01:20:43) Child Prodigies, Species Lifespan & Mitochondrial Metabolism; Aging

(01:28:56) Lifestyle & Aging: Exercise, Fasting; Inflammation, Sleep, Stimulants

(01:37:06) Energetic Stress Signals, GDF-15, Cancer, Heart Failure

(01:42:18) Genes, Lifestyle & Aging

(01:47:54) Gray Hair Reversal, Stress; Inflammation & Aging

(01:57:37) Energy Recovery, Sleep & Mitochondrial Function, Stress, Meditation

(02:05:16) Tools: Yoga Nidra, NSDR; Pre-Sleep Relaxation, Energy & Restorative Sleep

(02:10:58) Diet & Individualization, Clinical Trials; Mitochondria & Nutrition, Keto

(02:20:14) Alcohol & Energy Budget; Stress

(02:25:02) Exercise, Increase Mitochondria, Overtraining; Resistance & Growth

(02:33:06) Sponsor: Waking Up

(02:34:41) Supplements & Mitochondria Health, Deficiencies, SS31, Methylene Blue

(02:41:31) Energy Flow & Experiences, Balance

(02:49:13) Transform Through Resistance, Energetic Awareness, Connection

(02:56:05) Food Overconsumption & Mitochondria Disruption; Tissues & Mitochondria

(03:01:02) Mitochondrial Health Test; Tool: Ways to Increase Energy; Meditation

(03:06:10) Peptides; Fertility Supplements, Urolithin A; Electromagnetic Fields

(03:12:16) Acknowledgements

(03:14:15) Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter

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