The Huberman Lab Podcast discusses neuroscience: how our brain and its connections with the organs of our body control our perceptions, our behaviors, and our health. We also discuss existing and emerging tools for measuring and changing how our nervous system works. Dr. Andrew Huberman is a tenured Professor of Neurobiology and Ophthalmology at Stanford School of Medicine. His laboratory studies neural regeneration, neuroplasticity, and brain states such as stress, focus, fear, and optimal performance. For more than 20 years, Dr. Huberman has consistently published original research findings and review articles in top-level peer-reviewed journals, including Nature, Science, Cell, Neuron, and Current Biology. He is a regular member of several National Institutes of Health review panels and a Fellow of the McKnight Foundation and the Pew Charitable Trusts. Dr. Huberman regularly consults for technology development companies, professional athletic organizations, and various units of U.S. and Canadian Special Operations.
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair
In this Huberman Lab Essentials episode, my guest is Dr. David Sinclair, PhD, a professor of genetics at Harvard Medical School and a leading expert on the biology of aging.
We discuss the cellular and molecular mechanisms of aging—and how specific behaviors, such as fasting, regular exercise and NAD⁺-boosting compounds like NMN, can activate the body's natural longevity pathways. This discussion highlights how lifestyle choices profoundly influence the aging process and may even slow or reverse key aspects of biological aging.
Read the episode show notes at hubermanlab.com.
Thank you to our sponsors
AGZ by AG1: https://drinkagz.com/huberman
David: https://davidprotein.com/huberman
Eight Sleep: https://eightsleep.com/huberman
Timestamps
(0:00) David Sinclair
(0:20) Longevity, Anti-Aging, Aging as a Disease
(2:27) Causes of Aging; Epigenome & Genes
(4:53) CD & Scratches Analogy, DNA, Silencing & Expressing Genes
(6:44) Physical Appearance & Aging
(7:36) Sponsor: David
(8:54) Childhood Development & Aging, Horvath Clock, Accelerate Aging
(11:30) Rates of Puberty & Aging, Growth Hormone
(12:37) Body Size & Longevity; Epigenetics
(13:07) Fasting, Calorie Restriction & Longevity, Sirtuins, Insulin & Glucose
(16:31) Tool: Skip a Meal
(17:07) Longer Fasts & Autophagy, “Deep Cleanse”
(18:07) Sponsor: AGZ by AG1
(19:36) Fasting, Fluids, Electrolytes
(20:16) Sirtuins, Glucose, mTOR & Fasting; Leucine, Tool: Pulsing Behaviors
(24:24) Breaking a Fast, Tools: Do Your Best; Transitions
(27:00) Sirtuins, NAD, NMN Supplementation
(29:04) Sponsor: Eight Sleep
(31:10) Iron & Senescent Cells; Personalize Medicine
(32:40) Tool: Blood Markers, CRP
(34:50) Tool: Aerobic & Resistance Exercise
(35:55) Estrogen, Fasting & Fertility; Aging & Rejuvenation
(38:20) Acknowledgements
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